HCN1 Channels Constrain Synaptically Evoked Ca2+ Spikes in Distal Dendrites of CA1 Pyramidal Neurons

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HCN1 Channels Constrain Synaptically Evoked Ca2+ Spikes in Distal Dendrites of CA1 Pyramidal Neurons

HCN1 hyperpolarization-activated cation channels act as an inhibitory constraint of both spatial learning and synaptic integration and long-term plasticity in the distal dendrites of hippocampal CA1 pyramidal neurons. However, as HCN1 channels provide an excitatory current, the mechanism of their inhibitory action remains unclear. Here we report that HCN1 channels also constrain CA1 distal dend...

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A Behavioral Role for Dendritic Integration HCN1 Channels Constrain Spatial Memory and Plasticity at Inputs to Dendrites of CA1 Pyramidal Neurons

It has come to our attention that panels D, E, and G in Figure 6 of Nolan et al. (Cell 119, 719–732, November 2004) are incorrectly labeled. The symbols for control (HCN1 ) and forebrain-restricted HCN1 knockout (HCN1) are reversed. The closed symbols in these panels correspond to data from HCN1 mice, whereas the open symbols refer to data from HCN1 mice. Note that throughout the rest of the pa...

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Synaptically activated Ca2+ waves and NMDA spikes locally suppress voltage-dependent Ca2+ signalling in rat pyramidal cell dendrites.

Postsynaptic [Ca(2+)](i) changes contribute to several kinds of plasticity in pyramidal neurons. We examined the effects of synaptically activated Ca(2+) waves and NMDA spikes on subsequent Ca(2+) signalling in CA1 pyramidal cell dendrites in hippocampal slices. Tetanic synaptic stimulation evoked a localized Ca(2+) wave in the primary apical dendrites. The [Ca(2+)](i) increase from a backpropa...

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ژورنال

عنوان ژورنال: Neuron

سال: 2007

ISSN: 0896-6273

DOI: 10.1016/j.neuron.2007.11.015