HCN1 Channels Constrain Synaptically Evoked Ca2+ Spikes in Distal Dendrites of CA1 Pyramidal Neurons
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چکیده
منابع مشابه
HCN1 Channels Constrain Synaptically Evoked Ca2+ Spikes in Distal Dendrites of CA1 Pyramidal Neurons
HCN1 hyperpolarization-activated cation channels act as an inhibitory constraint of both spatial learning and synaptic integration and long-term plasticity in the distal dendrites of hippocampal CA1 pyramidal neurons. However, as HCN1 channels provide an excitatory current, the mechanism of their inhibitory action remains unclear. Here we report that HCN1 channels also constrain CA1 distal dend...
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The importance of long-term synaptic plasticity as a cellular substrate for learning and memory is well established. By contrast, little is known about how learning and memory are regulated by voltage-gated ion channels that integrate synaptic information. We investigated this question using mice with general or forebrain-restricted knockout of the HCN1 gene, which we find encodes a major compo...
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It has come to our attention that panels D, E, and G in Figure 6 of Nolan et al. (Cell 119, 719–732, November 2004) are incorrectly labeled. The symbols for control (HCN1 ) and forebrain-restricted HCN1 knockout (HCN1) are reversed. The closed symbols in these panels correspond to data from HCN1 mice, whereas the open symbols refer to data from HCN1 mice. Note that throughout the rest of the pa...
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ژورنال
عنوان ژورنال: Neuron
سال: 2007
ISSN: 0896-6273
DOI: 10.1016/j.neuron.2007.11.015